报告人简介:

蔡飞燕，中国科学院深圳先进技术研究院研究员，博士生导师，深圳市杰青。2008年获武汉大学凝聚态物理博士学位；同年加入深圳先进技术研究院生物医学与健康工程研究所工作，历任助理研究员，副研究员，研究员；2019-2020年美国密西西比大学国家物理声学中心任访问学者。迄今已主持国家自然科学基金4项，科技部重点研发计划子课题2项，深圳市重点项目2项；在JASA、Physical Review系列、Nature系列等发表论文70余篇，引用3300余次，相关工作获美国物理学会“物理精选”和“编辑推荐”报道，H指数30；授权中国发明专利30余项，美国发明专利2项；获得2017年国家技术发明二等奖（2/6），2019年深圳市自然科学一等奖（3/5）。目前主要的研究方向为声镊理论、技术及其在生物医学工程中的应用。

报告摘要：

Optical tweezers, recognized with the 2018 Nobel Prize in Physics, have showcased exceptional capabilities in manipulating micro- and nanoparticles. In comparison, acoustic tweezers provide stronger radiation forces, greater penetration depth, and reduced thermal damage, making them particularly suitable for biological applications, especially in vivo. Nonetheless, traditional acoustic tweezers face several challenges such as long wavelengths, diffraction limits, and rigid designs, limiting their precision and broader application in biomedicine. In this presentation, I will share our advancements in shaping sound waves for advanced acoustic tweezers and address these challenges. First, we designed localized gradient acoustic field to create a precise platform for high-throughput cellular manipulation. Second, we developed 3D acoustic tweezers to enable multidimensional manipulation in complex environments. Third, we innovated structured resonant fields to facilitate controllable trapping and releasing, laying the groundwork for targeted drug delivery near vascular stents. Finally, I will prospect ultrasound-assisted drug delivery, both in vivo and in vitro, and explore the future development of on-demand acoustic tweezer technologies tailored for practical medical applications.