姓 名：全珂
职 称：副教授
导师资格：硕士生导师
邮 箱：quanke518@126.com
研究方向：CRISPR/Cas活性调控方法的构建及其便携式生物传感器的开发；病原菌的可视化检测与防控
简介：全珂，理学博士，副教授，湖南省优秀青年科学基金获得者，长沙理工大学“湖湘学者”青年英才，细胞化学湖南省重点实验室副主任。2019年5月于湖南大学获得分析化学博士学位，同年6月加入长沙理工大学。主持国家自然科学基金面上项目、青年项目，湖南省自然科学基金青年B类项目（原省优秀青年基金项目），湖南省教育厅优秀青年项目等多项课题。以第一作者或通讯作者在 Angew. Chem. Int. Ed.、ACS Nano、Chem. Sci.、Anal. Chem.、CCS Chem 等SCI期刊发表论文多篇，授权发明专利2项（其中转化1项）。获评长沙理工大学优秀党支部书记、“双带头人”标兵。指导学生获全国大学生生命科学竞赛三等奖3项、省级二等奖1项。
代表性论文：
(1) Quan Ke; Li Xiaoyuan; Deng Jiaqi; Chen Weiju; Zou Zhen*; Chen Kun; Wu Linlin; Liu Juewen* and Qing Zhihe*. Pt-Decorated Gold Nanoflares for High-Fidelity Phototheranostics: Reducing Side-Effects and Enhancing Cytotoxicity toward Target Cells. Angew. Chem. Int. Ed., 2024, 63：e202402881.
(2) Wang Jiaoli;Liu Shiyuan; Liu Xiaoyi; Chen Yu; Liu Jianbo; Wang Kemin; Quan Ke* and Huang Jin*.Entropy-Driven Disassembly of Logic-Gated DNA Nanospheres: An All-in-One Platform for Precise Cancer Diagnosis In Vivo.ACS Nano, 2025, 19: 39420–39429.
(3) Chen Kun; Jin Ming; Shi Jianghui; Tang Jing; Qiu Xueying; Quan Ke* and Qing Zhihe*.Bivariate-gated DNA nanoreactors for high-fidelity amplified imaging of tumor cells.Chem. Commun., 2025,61: 14681-14684.
(4) Lei Yanli; Liu Xiang; Fu Guangwei; Zhao Shuwu; Wang Xinyu; Chen Yulai; Chen Kun; Quan Ke* and Qing Zhihe*.Surface Passivation of Fe3O4 Nanoparticles: Avoiding Degradation, Preserving Magnetism, and Facilitating Ligand Modification for Better Biomedical Analysis.Anal. Chem., 2025, 97: 17020-17028.
(5) Quan Ke; Zeng Yuqing; Gao Sijia; Lei Yanli; Yang Le*; Zhou Yibo; Lucky Poh Wah Goh and Qing Zhihe*.Metal-bearing Nanomaterials for Oral Antibacteria: Mechanisms and Applications.ASEM, 2025, 2: 100141.
(6) Gao Yuan; Bai Bingfeng; Mao Zenghui; Yang Xiao; Shi Yi; Zhang Bo; Quan Ke*; Qing Zhihe*. An all-in-one Smartphone-assisted Ratiometric Fluorescent Device for Visual and Quantitative Detection of Glutathione, Talanta, 2024, 281: 126805.
(7) Quan Ke; Zeng Yuqing; Zhang Wenke; Li Fengfeng; Li Mengjiao; Qing Zhihe*. One-step, reagent-free construction of nano-enzyme as visual and reusable biosensor for oxidase substrates, Anal. Chim. Acta, 2024, 1285: 342008.
(8) Quan Ke; Tong Jiajie; Chen Lifang; Fang Shuyao; Li Mengjiao; Wu Linlin; Qing Zhihe*. Freezing-directed construction of enzyme/nano interfaces: Reagentless conjugation, superior activity, and better stability, Chin. Chem. Lett., 2024, 35: 108894.
(9) Quan Ke; Wang Jiaoli; Li Jing; Wang Kemin; Huang Jin*. An endogenous miRNA-initiated hybridization chain reaction and subsequent DNAzyme activation for cellular theranostics,CCS Chem., 2022, 4：3505-3515.
(10) Quan Ke; Yi Cuiping; Yang Xiaohai; He Xiaoxiao; Huang Jin*; Wang Kemin*. FRET- based nucleic acid probes: Basic designs and applications in bioimaging, Trends Anal. Chem., 2020, 124: 115784.
(11) Quan Ke; Li Jing; Wang Jiaoli; Xie Nuli; Wei Qiaomei; Tang Jinlu; Yang Xiaohai; Wang Kemin; Huang Jin*; Dual-microRNA-controlled double-amplified cascaded logic DNA circuits for accurate discrimination of cell subtypes. Chem. Sci., 2019, 10: 1442-1449.
